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Worried About Swelling? The Truth About Kybella Side Effects

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A double chin is one of those features that tends to draw attention in photos and video calls, and it’s not unusual for people to feel self-conscious about it. 

In fact, a consumer survey revealed that 73% of more than 7,000 respondents said they were bothered by excess fat under the chin or neck. With this, a large number of people seeking solutions have made non-surgical treatments increasingly popular.

Among these options, Kybella has gained recognition as the first and only FDA-approved injectable treatment that permanently destroys fat cells under the chin. 

Patients are drawn to the idea of slimming their profile without the need for surgery, but what often gets less attention are the possible downsides, especially the Kybella side effects.

Swelling is the most common response after injections, but it’s not the only one. For anyone considering treatment, the key questions usually are: “How long does Kybella swelling last?” and “Is there anything I can do to reduce it?”

Keep reading as we’ll tell you exactly what to expect, from the most common side effects of Kybella to practical advice on how to reduce Kybella swelling, so you can feel prepared before booking your treatment.

Kybella Side Effects: What You Need to Know

Before scheduling your first Kybella treatment, it is helpful to understand the potential side effects associated with it. While this injectable has been FDA-approved and widely used for years, it’s not without temporary reactions. 

Common Side Effects of Kybella

The good news is that most side effects of Kybella are mild to moderate and resolve on their own. Patients may notice:

  • Swelling: the most common effect, especially in the first few days after treatment
  • Bruising: localized bruising at the injection site
  • Redness or warmth: a temporary sign of inflammation in the treated area
  • Tenderness or discomfort: usually described as soreness or sensitivity
  • Firmness or small nodules: temporary hardness as the fat cells are breaking down
  • Numbness: tingling or reduced sensation around the injection site
  • Mild nausea: less common but possible after injections

These reactions are temporary and part of the body’s natural healing response. Most patients find that swelling and tenderness are the most noticeable effects, while bruising and redness fade within days.

Less Common but Rare Side Effects of Kybella

Like any injectable, Kybella injections carry rare risks. Though uncommon, reported side effects may include:

  • Difficulty swallowing (dysphagia)
  • Throat or mouth pain
  • Temporary uneven smile or facial muscle weakness due to nerve irritation
  • Skin tissue injury or infection at the injection site
  • Hair loss in the treated area (men)

These rare side effects are usually temporary, but they highlight the importance of why Kybella should only be performed by an experienced, qualified provider like InjectCo. Proper technique and precise placement significantly reduce the likelihood of serious complications.

Kybella Swelling: Why It Happens and What to Expect

Swelling is by far the most common side effect after Kybella injections, and it’s actually a sign that the treatment is working. 

The active ingredient, deoxycholic acid, breaks down fat cells under the chin. As your body begins clearing away these damaged cells, an inflammatory response kicks in, which shows up as puffiness in the treated area.

For most people, this swelling is most noticeable within the first couple of days. Some even describe it as a temporary “bullfrog” look, especially after the first session, when the largest number of fat cells are being targeted. 

While it can feel dramatic, this swelling is a normal and expected part of the healing process.

How Long Does Kybella Swelling Last?

The length of swelling after Kybella varies from person to person, but there are some general timelines you can expect.

  • Peak swelling: Usually occurs within the first 24 to 48 hours after treatment.
  • Typical duration: For most patients, swelling lasts about 5 to 7 days.
  • Lingering puffiness: In some cases, mild swelling may stick around for up to two to four weeks, especially after the first session when the largest number of fat cells are being dissolved.

It’s also common for the swelling to be more noticeable after your first Kybella treatment. That’s because the initial session usually involves the greatest amount of fat breakdown. Each subsequent treatment tends to produce less swelling as fewer fat cells remain in the area.

How to Reduce Kybella Swelling and Recover Comfortably

While some degree of swelling is unavoidable, there are simple strategies that can make the recovery process more comfortable. 

If you’re wondering how to reduce Kybella swelling, these tips can help speed things along:

1. Use Ice Packs Wisely

  • Apply a cold compress or wrapped ice pack to the treated area in short intervals (10–15 minutes at a time).
  • Always wrap ice in a clean towel to avoid skin irritation or frostbite.

2. Keep Your Head Elevated

  • Sleep with an extra pillow or use a wedge pillow to keep your head slightly upright. Elevation helps reduce fluid buildup overnight and minimizes morning puffiness.

3. Avoid Blood Thinners Before and After

  • Substances like aspirin, ibuprofen, fish oil, and vitamin E can increase bruising and swelling.
  • If you take prescription blood thinners, speak with your provider before scheduling treatment.

4. Consider OTC Relief

  • Over-the-counter antihistamines (such as cetirizine) or pain relievers like acetaminophen may help with discomfort and inflammation.
  • Of course, always check with your provider before adding any new medication.

5. Stay Hydrated and Be Gentle

  • Drinking water supports your body’s natural healing process.
  • Avoid massaging or pressing on the injection area, which could worsen swelling.

With the right care, Kybella swelling usually subsides in days, leaving you on track for a slimmer, more defined chin profile.

When Should You Call Your Provider?

While most Kybella side effects are temporary and mild, it’s important to know when professional guidance is necessary. Contact your provider if you notice:

  • Excessive or prolonged swelling that doesn’t improve after 1–2 weeks.
  • Severe pain not relieved by over-the-counter medication.
  • Signs of infection: redness spreading beyond the injection site, pus, or fever.
  • Persistent numbness or unusual tingling.
  • Difficulty swallowing or any asymmetry in your facial expressions.

These instances are uncommon, but reaching out promptly ensures any rare complications are managed effectively. Remember, your provider is there to help you recover safely and achieve the best possible results.

Kybella Confidence Starts Here with InjectCo

Kybella swelling is normal and expected, and it’s part of the fat-dissolving process. Other side effects of Kybella, such as bruising, tenderness, redness, or temporary numbness, are also common and usually resolve on their own within days to a couple of weeks.

Understanding how long Kybella swelling lasts and following simple aftercare tips on how to reduce Kybella swelling can make your recovery more comfortable and predictable.

For lasting, natural-looking results, it’s important to work with an experienced, qualified provider. At InjectCo, we always start with a thorough consultation to review your personal goals, explain what to expect, and create a treatment plan specifically made for you.

Ready to say goodbye to your double chin for good? Book a free virtual consultation with us today and get a slimmer, more defined jawline safely with the right provider.

Frequently Asked Questions

Does Kybella have long-term side effects?

Most side effects from Kybella injections, such as swelling, bruising, or tenderness at the injection site, are temporary and resolve within days to a couple of weeks. Long-term complications are extremely rare when treated by a qualified provider.

How long does Kybella last?

Kybella treatment permanently destroys targeted fat cells under the chin. While the results are long-lasting, maintaining a stable weight is important to prevent new fat accumulation in the area.

How many treatment sessions of Kybella will I need?

The number of Kybella treatment sessions depends on your individual anatomy and goals. Most patients require 2 to 4 sessions, spaced at least one month apart, for optimal results. Your provider will create a personalized plan during the consultation.

Is Kybella FDA-approved?

Yes. Kybella is the only FDA-approved injectable specifically designed to reduce double chin fat using deoxycholic acid injections.

Does Kybella change face shape?

Kybella injections target submental fat to contour the jawline and reduce a double chin. While the procedure enhances profile definition, it doesn’t alter bone structure or overall face shape.

What should I expect after Kybella is injected?

After Kybella is injected, expect some swelling, bruising, redness, or tenderness at the injection site. Swelling is usually most noticeable in the first few days and gradually resolves within a week.

Written By:
Jen, BSN, RN, Clinical Aesthetics Injector, Vice President
I’m Jen, a dedicated Registered Nurse with over 13 years of experience, based in Waxahachie, TX. I hold a Bachelor of Science in Nursing and earned my Aesthetic Medical Certification in Botulinum Toxin and Dermal Fillers in 2018. As a master aesthetic injector and cadaver-certified practitioner, I specialize in achieving ultra-natural, balanced results—so much so that patients often request me by name.

My passion for aesthetics goes beyond enhancing beauty; I’m deeply committed to education and empowerment. I make it a priority to ensure my patients feel confident and informed when making decisions about their personalized treatment plans. Beyond my work with patients, I also train other aesthetic injectors weekly, sharing advanced techniques and providing hands-on instruction to help them refine their skills.

Honesty and artistry define my approach—I believe in creating enhancements that highlight each individual’s natural beauty. The most rewarding part of my role is seeing the transformation that happens when someone’s confidence radiates from within. My consultations are designed to craft a tailored plan that truly reflects each patient’s goals, and I pride myself on listening intently and respecting their vision.

Collaboration is key, whether I’m working with patients or my team. My goal is to create an uplifting experience where everyone feels heard, encouraged, and excited about their journey.

I look forward to helping you shine, inside and out!

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