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PicoWay vs CO2 Laser: Which Skin Rejuvenation Treatment Is Right for You?

Table Of Contents

Your skin shows the years. Fine lines around your eyes. Sun damage creating uneven tone. Texture that’s lost its smoothness. You’re ready to do something about it, and laser skin rejuvenation keeps coming up in your research.

But here’s where it gets confusing. Some clinics talk about PicoWay for gentle rejuvenation. Others recommend CO2 for dramatic resurfacing. The two treatments sound completely different.

Let’s break down exactly how these laser technologies work, what results they deliver, and which one makes sense for your specific skin goals.

The Core Difference: Gentle vs Aggressive

PicoWay: Non-Ablative Rejuvenation

PicoWay delivers rejuvenation without removing skin layers. Ultra-fast picosecond pulses create pressure waves that trigger your body’s healing response.

Key characteristics:

  • No skin removal
  • Stimulates collagen from within
  • Surface stays intact
  • Minimal redness (2-4 hours)
  • Return to work immediately
  • Results develop gradually

CO2: Ablative Resurfacing

CO2 performs aggressive skin removal. The laser vaporizes microscopic columns of damaged skin to reveal fresh layers underneath.

Key characteristics:

  • Removes damaged tissue
  • Forces skin rebuilding
  • Surface is wounded
  • Visible recovery needed
  • Take time off work
  • Results appear dramatically

Think of it this way. PicoWay gently encourages your skin to renew itself. CO2 forcefully removes damaged tissue and forces your body to rebuild.

Side-by-Side Treatment Comparison

FactorPicoWayCO2 Laser
Treatment typeNon-ablativeAblative
Downtime2-4 hours redness5-10 days recovery
Pain levelMild snappingSignificant (numbing required)
Sessions needed3-5 sessions1 session typically
Results timelineGradual over 3-6 monthsDramatic after healing
Improvement level20-30%50-70%
Cost per session$400-$800$1,500-$3,500
Total investment$1,200-$4,000$1,500-$3,500
Skin tone safetyAll types I-VILimited (avoid darker tones)

How Each Technology Actually Works

PicoWay Technology Explained

PicoWay uses ultra-short pulse duration measured in picoseconds. That’s one trillionth of a second.

The process:

  1. Ultra-fast pulses create photoacoustic effect (pressure waves)
  2. Pressure waves shatter pigment particles
  3. Fibroblasts get stimulated deep in dermis
  4. Body interprets this as controlled micro-injury
  5. Collagen production ramps up naturally
  6. Elastin fibers strengthen over time
  7. Skin quality improves over 2-3 months

Your skin surface remains undamaged. No peeling. No oozing. No raw, vulnerable skin.

CO2 Laser Technology Explained

CO2 lasers use fractional technology to remove tiny columns of skin tissue.

The process:

  1. Laser creates thousands of microscopic ablation zones
  2. Each wound removes damaged skin tissue
  3. Surrounding healthy skin speeds healing
  4. Body removes damaged tissue aggressively
  5. Fresh skin cells replace ablated areas
  6. Massive collagen production occurs
  7. Remodeling continues for 3-6 months

The intensity is adjustable. Lighter settings remove superficial damage. Aggressive settings penetrate deeper for maximum improvement.

What Each Treatment Does Best

PicoWay Excels At

Skin concerns it addresses:

  • Fine lines and early wrinkles
  • Subtle texture issues
  • Mild sun damage
  • Small pore size
  • Light pigmentation
  • Preventative anti-aging
  • Overall skin quality maintenance

Ideal candidates:

  • Ages 30-45 typically
  • Mild to moderate concerns
  • No downtime available
  • All skin tones welcome
  • Want natural-looking refresh
  • Prefer gradual improvement

CO2 Excels At

Skin concerns it addresses:

  • Deep wrinkles and folds
  • Severe sun damage
  • Pronounced texture problems
  • Moderate to severe acne scars
  • Significant skin laxity
  • Heavy pigmentation
  • Dramatic transformation needs

Ideal candidates:

  • Ages 50+ typically
  • Severe aging concerns
  • Can take week off
  • Lighter skin tones preferred
  • Want obvious results
  • Accept aggressive approach

Real Results Expectations

PicoWay Results Timeline

Session 1: Minimal visible change
Sessions 2-3: Subtle improvements appearing
Sessions 4-5: Noticeable texture smoothing
3 months post-treatment: Final results visible
Duration: Results last 1-2 years

Realistic improvements:

  • Fine lines soften 20-30%
  • Pores appear smaller
  • Texture feels smoother
  • Tone becomes more even
  • Skin looks refreshed naturally

CO2 Results Timeline

Days 1-5: Intense redness and swelling
Days 5-10: Peeling and healing
Weeks 2-4: Pink healing phase
Months 1-3: Continued improvement
Months 3-6: Final results emerge
Duration: Results last 3-5 years

Realistic improvements:

  • Wrinkles reduce 50-70%
  • Texture transforms dramatically
  • Scars improve significantly
  • Pigmentation clears substantially
  • Skin looks years younger

Downtime Reality Check

PicoWay Recovery Schedule

TimeWhat to Expect
Immediately afterMild redness like slight sunburn
2-4 hoursRedness fades completely
Next dayApply makeup normally
Week afterNo restrictions on activities

You can schedule PicoWay during lunch break. Return to work immediately. Nobody knows you had treatment.

CO2 Recovery Schedule

TimeWhat to Expect
Day 1-2Intense redness, feels like severe sunburn
Day 3-5Swelling peaks, skin begins peeling
Day 5-7Heavy flaking and shedding
Day 7-10Pinkness remains, no more peeling
Week 2-4Pink tone gradually fading
Month 1+Skin tone normalizing

Plan to stay home for at least one week. Stock healing ointment. Clear your calendar. You cannot hide CO2 recovery.

Pain and Comfort Levels

PicoWay Discomfort

During treatment:

  • Feels like mild snapping against skin
  • Brief sensation during each pulse
  • Most tolerate easily without numbing
  • Treatment takes 15-20 minutes
  • Discomfort ends immediately

After treatment:

  • Slight warmth for 1-2 hours
  • Mild tightness possible
  • No pain medication needed
  • Resume normal activities

CO2 Discomfort

During treatment:

  • Topical anesthetic applied 30-45 minutes before
  • Feel heat and intense sensation despite numbing
  • Treatment takes 30-60 minutes
  • Moderate discomfort throughout

After treatment:

  • Skin feels like severe sunburn for 24-48 hours
  • Healing ointment needed constantly
  • Prescription pain relief may be needed
  • Sleep elevated to reduce swelling

Skin Tone Safety Considerations

PicoWay for All Skin Tones

Safe for Fitzpatrick types I through VI (all skin tones).

Why it’s safe:

  • Non-ablative approach
  • No risk of hyperpigmentation
  • Photoacoustic effect minimizes heat
  • Ultra-fast pulses prevent thermal damage

Texas has incredibly diverse communities. PicoWay treats everyone safely.

CO2 Risks for Darker Skin

Risky for Fitzpatrick types IV through VI (medium to dark skin).

Why it’s risky:

  • Ablative resurfacing triggers inflammation
  • Inflammation causes hyperpigmentation in darker skin
  • Dark spots can be permanent
  • Many clinics refuse CO2 on darker tones

If you have medium to dark skin, PicoWay becomes the safer choice.

Cost Investment Breakdown

PicoWay Total Cost

Per session: $400-$800
Sessions needed: 3-5
Total investment: $1,200-$4,000
Results last: 1-2 years
Annual maintenance: $400-$800

CO2 Total Cost

Per session: $1,500-$3,500
Sessions needed: 1 (occasionally 2)
Total investment: $1,500-$3,500
Results last: 3-5 years
Maintenance needs: Minimal

Total costs are similar when accounting for multiple PicoWay sessions.

Combination Treatment Strategy

You don’t have to choose just one. Many people benefit from combining both technologies.

Option 1: CO2 First, PicoWay Maintenance

Start with CO2 for dramatic improvement. Then maintain results with annual PicoWay sessions. This gives big initial results followed by ongoing quality maintenance.

Option 2: PicoWay First, CO2 If Needed

Do a series of PicoWay treatments first. If results don’t meet expectations, upgrade to CO2 later. Starting gentle lets you gauge whether you actually need the aggressive option.

Option 3: Hybrid Approach

Use CO2 on severely damaged areas like around the mouth. Treat the rest of your face with PicoWay for overall improvement. This balances dramatic results with manageable recovery.

Making Your Decision

Choose PicoWay if you want subtle, natural-looking improvement without downtime. It’s perfect for early aging, busy schedules, and people who can’t hide recovery.

Choose CO2 if you want dramatic transformation and can handle real recovery time. It’s necessary for severe concerns that won’t respond to gentler options.

At InjectCo, we offer both PicoWay and Fractional CO2 in our comprehensive laser division. Our master nurse injectors assess your specific concerns during consultation. We’ll recommend which technology addresses your goals most effectively.

Book your free consultation to discuss which laser rejuvenation option fits your skin goals and lifestyle. Let’s create clearer, smoother, more youthful skin using the technology that makes sense for you.

Frequently Asked Questions

Can I do PicoWay and CO2 at the same time?

Not in the same session. But you can do CO2 on specific problem areas and PicoWay on the rest of your face during separate appointments. Your provider designs a hybrid plan if appropriate.

How long do results last from each treatment?

PicoWay results last 1-2 years with proper skincare and sun protection. CO2 results last 3-5 years or longer. Both require maintenance eventually as natural aging continues.

Which treatment hurts more?

CO2 hurts more both during and after treatment. PicoWay feels like mild snapping. CO2 requires numbing and feels like significant heat even with anesthetic.

Can I wear makeup after treatment?

After PicoWay, yes the next day. After CO2, no for at least 5-7 days until skin has re-epithelialized. Makeup on raw CO2 skin risks infection.

Will insurance cover either treatment?

No. Both are cosmetic procedures. Insurance doesn’t cover aesthetic treatments. You’ll pay out-of-pocket or use financing like CareCredit or Cherry.

Which treatment is better for acne scars?

Depends on scar severity. Mild acne scars respond to PicoWay. Moderate to severe acne scars need CO2’s aggressive resurfacing. Your consultation determines which gives adequate improvement.

Can men get these treatments?

Absolutely. Both treatments work equally well on male skin. Many men choose laser rejuvenation for professional appearance or personal preference.

What if I have active acne?

Treat active acne first before either laser rejuvenation. Both treatments can worsen active breakouts. Get your skin clear, then proceed with rejuvenation.

Written By:
Kiara DeWitt, BSN, RN, CPN, Advanced Clinical Nurse Injector


Kiara DeWitt, BSN, RN, CPN founded InjectCo in early 2021 while also heading up the neurosurgery + neurology unit at Cook Children’s Pediatric Hospital as lead clinical educator. After completing her Bachelor's degree at Texas Christian University, Kiara realized just how much the aesthetic medicine industry was missing, wishing it was more focused on ethical decision-making and building relationships. Kiara’s dream was to create an atmosphere for her patients where they feel loved, empowered, and comfortable. She believes in a “lead to serve” mentality, hoping to create a more personal connection with both her patients and team alike. Kiara curated a team of 13 professionals across eight clinics, six of which are in DFW, one in Houston, and one in Austin.
Kiara loves nothing more than creating a collaborating, educational approach with her team, and thrives on personal and professional growth opportunities. She hopes that her patients feel heard and encouraged at every InjectCo visit and that they are truly excited about their personalized and well-designed aesthetic treatment plan. This love for education and safety in the industry led her to later found Texas Academy of Medical Aesthetics, an accredited training program that specializes in a 100+ hour aesthetic injector internship where students are able to train and shadow at all eight of InjectCo’s clinics.


Kiara’s patients recognize her and the entire InjectCo team as highly skilled and extremely thorough clinicians. She hopes to continue being a knowledgeable and approachable resource for clinical injectors across the country who are hoping to grow and scale their aesthetic business.

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