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Daxxify vs Botox Reviews: Which Wrinkle Treatment Wins?

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At some point, most of us start noticing subtle lines that don’t fade like they used to. Perhaps it’s the faint creases that linger around your mouth or the forehead lines that seem a little more defined each year. 

And so, millions of Americans are turning to wrinkle relaxers each year to refresh their appearance. In 2023, nearly 9.5 million neuromodulator procedures were performed in the United States, illustrating the growing prevalence of these treatments.

Now, with newer options like Daxxify, people are comparing Daxxify vs Botox reviews to figure out which injectable offers the best results. Botox has set the standard for decades, while Daxxify is gaining attention for its longer-lasting effects and unique formulation.

So, which one actually delivers the look you’re hoping for? Here, we’ll look at what real patients are saying, explore Daxxify vs Botox reviews and before-and-afters, and share expert insights to help you decide which wrinkle treatment might win for you.

Daxxify vs Botox Reviews: What Real Patients Are Saying

When you read through Daxxify vs Botox reviews, you’ll notice a pattern: both treatments earn loyal fans, but for slightly different reasons. Many patients love the fast, familiar results of Botox, while others say Daxxify finally gives them the longevity they’ve been waiting for.

Below are real patient impressions collected from InjectCo and verified online platforms. They reveal what people actually experience during and after their wrinkle treatments: the good, the surprising, and even the mixed.

Botox Reviews

“I couldn’t be happier with my Botox results. The treatment was quick, painless, and left me looking refreshed and not frozen. Six months later, I still feel more confident every time I look in the mirror.”

This patient shared that the overall Botox experience was smooth. She loved how natural her results looked and mentioned feeling a huge boost in confidence for seeing the same Botox results even after six months.

“I was nervous at first, but the Botox injections didn’t hurt at all. My provider made me feel comfortable, and the results were better than I expected.”

Another patient described her first Botox session as much easier than she expected. She emphasized how reassurance and gentle technique from her injector helped her feel completely at ease.

“After getting Botox in my masseter muscles, my jaw pain disappeared in about three weeks. I can finally sleep without clenching.”

Some patients turn to Botox for functional reasons rather than purely cosmetic ones. One reviewer shared that the relief from her jaw pain was life-changing.

“My Botox was placed too low, and it affected how my eyes looked.”

Of course, not every experience is perfect. One review mentioned a placement issue and temporary side effects such as drooping or swelling.

Overall, most patients report smoother skin, softer lines, and a confidence boost that lasts several months. Many return for maintenance treatments every three to four months to keep their results consistent.

Daxxify Reviews

“I used to come in for Botox every few months. With Daxxify, I’m at the 4½-month mark and still don’t need a touch-up. The results appeared fast and look completely natural.”

One patient said she switched from Botox to Daxxify because she wanted something that would last longer, and she noticed a big difference.

“I started seeing changes about two days after my Daxxify treatment. My skin looked smoother, and people kept asking if I’d switched skincare routines.”

Another reviewer shared that her Daxxify results appeared faster than expected. She said the quick onset made her feel more confident heading into an upcoming event.

“I’d never done any kind of injection before, so I was nervous. But Daxxify was way easier than I thought. There was no pain, and I could already see my skin improving.”

A first-time injectable patient also expressed how surprised she was by the comfort level. She shared that she’s now more open to regular treatments thanks to how natural the results looked.

“Daxxify was more painful for me, and my eyelid drooped afterward. It’s also pricier, so I wish I’d known that before.”

Not every Daxxify review was positive, though. One patient found the experience a bit more uncomfortable.

Even with mixed feedback, the majority of Daxxify vs Botox reviews before and after comparisons show patients satisfied with both: Botox for its trusted, subtle results, and Daxxify for its impressive longevity, sometimes lasting up to six months or more.

Daxxify vs Botox: The Difference

Both Daxxify and Botox are FDA-approved neuromodulators designed to smooth expression lines, but they’re not identical. Knowing their small distinctions can help you decide which treatment fits your lifestyle and goals.

How Each Injectable Works

Both Daxxify and Botox use a purified form of botulinum toxin type A to relax the facial muscles that cause wrinkles. When these muscles temporarily stop contracting, the skin above them appears smoother and more rested.

Their difference is in what surrounds that active ingredient. 

Botox uses human serum albumin as a stabilizer, while Daxxify replaces it with a proprietary peptide-based formula. This unique formulation helps Daxxify bind more effectively to nerve endings, allowing its effects to last longer, often up to six months for many patients.

Botox, on the other hand, has been trusted for over 20 years and remains the gold standard in neuromodulator treatments. Its predictable, precise results make it a top choice for those who want a tried-and-true option with decades of clinical data behind it.

How Long Do Results Last?

When reading Daxxify vs Botox reviews before and after, longevity is one of the most noticeable differences between the two. Most Botox patients enjoy results for about three to four months, while Daxxify can extend that window to roughly five or even six months in some cases.

That longer duration means fewer appointments per year, which is a big advantage for those with busy schedules or anyone looking for longer-lasting wrinkle reduction.

Comfort, Downtime, and Recovery

Both treatments are quick, minimally invasive, and require little to no downtime. Most patients describe the injections as mildly uncomfortable at worst, with results appearing within a few days. Botox typically shows results in three to five days, while Daxxify may start working in as little as two.

Mild swelling or redness can occur, but usually fades within hours. Based on Daxxify vs Botox reviews, comfort levels are similar, though a few patients mention slightly more pressure with Daxxify injections, but that usually depends on individual sensitivity and injector technique.

In short, Botox delivers reliable, natural results, while Daxxify stands out for longevity and faster onset. Both have their advantages, and the right choice ultimately depends on your goals, comfort level, and how often you want to maintain your results.

Daxxify vs Botox: So, Which Wrinkle Treatment Wins?

When it comes to Botox and Daxxify reviews, there’s no single “winner.” Both injectables deliver smoother, more youthful-looking skin. They simply offer different experiences in terms of longevity, feel, and maintenance.

For many patients, Botox remains a trusted favorite thanks to its natural results and consistent performance. It’s ideal for those who prefer a subtle refresh and don’t mind touch-ups every few months. Meanwhile, Daxxify is gaining fans for its longer duration and modern peptide formulation, appealing to patients who want fewer appointments without sacrificing results.

At InjectCo, our licensed master nurse injectors specialize in both Daxxify and Botox treatments. Each session begins with a detailed consultation to understand your goals, assess your facial anatomy, and recommend a plan that delivers natural, balanced results.

Not sure which one’s right for you? Book a free virtual consultation with us today and find out which wrinkle treatment fits you best, because feeling confident in your own skin is always worth it.

Frequently Asked Questions

What are the main differences between Daxxify and Botox?

The main differences between Daxxify and Botox are in their formulation and how long they last. Botox uses human serum albumin, while the approved Daxxify formula is stabilized with peptides, which may help deliver longer-lasting results for some patients. Both treat dynamic wrinkles like frown lines, crow’s feet, and forehead lines, but Daxxify can often last around six months or more compared to Botox’s three to four months.

How does Daxxify compare to Botox in terms of longevity and results?

Botox typically smooths fine lines and facial wrinkles for about 3–4 months, while Daxxify’s peptide technology can maintain results closer to six months. However, both offer excellent results when injected precisely in the right injection sites by a skilled provider.

When comparing Daxxify vs Botox, which is better for first-time users?

Botox is often preferred for first-time users because its shorter duration allows you to test how your muscles respond. Once you’re familiar with how many units you typically need and how your face moves post-procedure, you can explore Daxxify for longer-lasting results. The best choice depends on your specific needs and the frequency of touch-ups you prefer.

Are there any medical conditions that might affect your eligibility for Daxxify or Botox?

Yes. Individuals with certain medical conditions, such as neuromuscular disorders (e.g., ALS, myasthenia gravis) or allergies to botulinum toxin ingredients, should avoid both treatments. It’s also worth noting that pregnancy, breastfeeding, or infections at the injection site are contraindications. Always consult your healthcare provider or injector before scheduling a procedure.

Can Daxxify and Botox be used together or alternated between treatments?

Yes, it’s possible to alternate between Botox and Daxxify, though combining them in the same session isn’t typical. Some patients switch to Daxxify after Botox to see if the longer-lasting results fit their schedule better. Your provider can create a custom plan to treat fine lines and vertical lines based on how your muscles respond to each formulation.

How do Daxxify and Botox differ from other neuromodulators on the market?

Compared to other neuromodulators like Dysport or Xeomin, both Botox and Daxxify offer consistent, low-risk options for softening dynamic wrinkles. Botox has been known for decades for its proven safety, while Daxxify’s peptide-based formula appeals to patients seeking a newer, longer-lasting alternative. Both can effectively treat facial wrinkles when tailored to your specific needs.

Written By:
Kiara DeWitt, BSN, RN, CPN, Advanced Clinical Nurse Injector


Kiara DeWitt, BSN, RN, CPN founded InjectCo in early 2021 while also heading up the neurosurgery + neurology unit at Cook Children’s Pediatric Hospital as lead clinical educator. After completing her Bachelor's degree at Texas Christian University, Kiara realized just how much the aesthetic medicine industry was missing, wishing it was more focused on ethical decision-making and building relationships. Kiara’s dream was to create an atmosphere for her patients where they feel loved, empowered, and comfortable. She believes in a “lead to serve” mentality, hoping to create a more personal connection with both her patients and team alike. Kiara curated a team of 13 professionals across eight clinics, six of which are in DFW, one in Houston, and one in Austin.
Kiara loves nothing more than creating a collaborating, educational approach with her team, and thrives on personal and professional growth opportunities. She hopes that her patients feel heard and encouraged at every InjectCo visit and that they are truly excited about their personalized and well-designed aesthetic treatment plan. This love for education and safety in the industry led her to later found Texas Academy of Medical Aesthetics, an accredited training program that specializes in a 100+ hour aesthetic injector internship where students are able to train and shadow at all eight of InjectCo’s clinics.


Kiara’s patients recognize her and the entire InjectCo team as highly skilled and extremely thorough clinicians. She hopes to continue being a knowledgeable and approachable resource for clinical injectors across the country who are hoping to grow and scale their aesthetic business.

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