What Happens When P-Shot Doesn’t Work? Options and Next Steps

The Priapus Shot, or P-Shot, is one of the most talked-about regenerative treatments for men’s sexual health today.

To put things in context: erectile dysfunction (ED) is far from rare. In the U.S., around 18.4 % of men aged 20 or older report some degree of erectile dysfunction — that’s over 18 million men! By age 40, about 40 % of men have some ED, and the likelihood continues rising with age.

So it’s no surprise that many men explore treatments like the P-Shot to restore sexual health, enhance erection quality, and revive confidence. Yet even with such promising potential, outcomes can vary, and not everyone experiences immediate results.

Why the P-Shot Might Not Work Right Away

The P-Shot treatment works by using growth factors from your own blood to stimulate tissue growth and improve blood vessels in the penis. These natural repair processes take time. Some men see improvement after a few weeks, while others may need multiple sessions before noticing significant changes in erection quality or male sexual function.

Several factors can affect how your body responds, including:

• Blood circulation and overall health: Conditions like diabetes, hypertension, or high cholesterol can impact blood flow to the erectile tissue.
• Severity of erectile dysfunction: Men with severe ED or long-term sexual dysfunction may need a combination of therapies.
• Lifestyle habits: Sleep, stress, alcohol use, and smoking can all influence how effectively your body heals and regenerates.
• PRP preparation and technique: Not all clinics follow the same standards for PRP treatment, which can affect the concentration of growth factors and overall results.

Remember, this is a regenerative treatment, not an instant fix. Your body’s red blood cells and platelets need time to activate the healing process that supports healthy tissue and sexual function.

Signs That the P-Shot May Not Be Working

If you’ve had your P-Shot and it’s been a few months with little to no change, it might feel discouraging. Here are some common signs that you may not be getting the full benefit yet:

• No noticeable improvement in erection quality or sexual stamina after 8–12 weeks
• Persistent erectile dysfunction symptoms or difficulty maintaining erections during sexual stimulation
• Ongoing issues with sex drive, emotional well-being, or sexual confidence
• Little change in Peyronie’s disease symptoms, such as curvature or scar tissue tightness

These signs don’t mean the treatment failed. They simply show that your body may need more time or a different approach to healing.

What to Do If You Don’t See Results

If you’re not seeing the outcome you expected, don’t lose hope. Here are practical steps to take:

1. Talk to your provider.

Start with a follow-up consultation. Your provider can review your medical history, blood sample results, and injection technique to see if the platelet-rich plasma concentration or injection site needs to be adjusted.

2. Review your health and habits.

Poor blood flow or an underlying medical condition can slow recovery. Addressing these through diet, exercise, and sleep can make a major difference in your sexual health.

3. Consider combination therapies.

Many men see better results by pairing the P-Shot with shockwave therapy, testosterone optimization, or oral medications used to treat Peyronie’s disease. These approaches complement PRP by improving blood vessels, smooth muscles, and erectile tissue function.

4. Explore other treatments.

Depending on your needs, options like a vacuum pump, penis pump, or alternative ED treatments may be added to your plan. These can help stimulate blood flow and maintain healthy tissue while your body continues healing from the P-Shot procedure.

5. Be patient and consistent.

Every man’s body is different. Clinical trials show that results from platelet-rich plasma PRP can continue to develop for several months. Staying consistent with your provider’s plan can lead to better outcomes over time.

How InjectCo Approaches Priapus Shot Results Differently

At InjectCo, your care doesn’t end after the injection. It begins there. Each P-Shot procedure is customized to your unique anatomy and goals. Here’s what sets our process apart:

• Personalized PRP preparation: We draw your blood sample, isolate the platelet-rich plasma, and ensure a concentrated dose of growth factors for optimal regeneration.
• Comfort-focused procedure: A topical numbing cream and local anesthetic are used so you stay comfortable during the injections along the penile shaft.
• Medical expertise: Every treatment is performed by experienced nurse injectors under physician supervision, ensuring safe and appropriate care for adult males seeking to treat erectile dysfunction or Peyronie’s disease.
• Holistic men’s wellness approach: Our team focuses on sexual medicine, hormone balance, and overall health, helping you address both the physical and emotional sides of sexual dysfunction.
• Ongoing support. From your first consultation to post-treatment check-ins, InjectCo guides you through every step with transparency and care.

When combined with healthy lifestyle habits, our approach helps men regain sexual function, improve blood flow, and feel more confident in their sexual performance.

It’s Not the End of the Road

Not seeing results right away from the P-Shot treatment doesn’t mean it won’t work. It may just mean your body needs more time or support. The key is working with a team that understands your unique situation and takes the time to find the appropriate treatment plan for you.

At InjectCo, we specialize in helping men reclaim confidence, improve erectile function, and enhance sexual experience through safe and proven treatment.

Book a same-day appointment today and find out how our master nurse injectors can help you restore confidence and balance in your sexual health.

Frequently Asked Questions

1. How long does it take to see results from the P-Shot?

Most patients notice subtle improvements in erection quality and sexual stamina within three to six weeks, though the full benefits can take up to 12 weeks or longer. Because the P-Shot treatment relies on your body’s natural healing process using platelet-rich plasma (PRP), it can take time for tissue growth, blood vessel repair, and nerve regeneration to occur.

2. Why doesn’t the P-Shot work for everyone?

Results can vary due to several factors, including overall health, blood circulation, hormonal balance, and the severity of erectile dysfunction. Lifestyle factors such as smoking, alcohol use, and poor sleep can also impact how well your body responds. Additionally, not all providers use the same PRP preparation techniques, which can affect growth factor concentration and outcomes.

3. What are the signs that my P-Shot didn’t work?

Common signs include:

• No improvement in erection quality or sexual performance after 8–12 weeks
• Persistent erectile dysfunction symptoms or difficulty maintaining erections
• No noticeable change in sensitivity or confidence during sexual activity
• Ongoing Peyronie’s disease symptoms, such as penile curvature or tightness

These signs don’t necessarily mean the treatment failed; they may simply indicate your body needs more time or a different approach.

4. Can I combine the P-Shot with other treatments?

Yes. Many men achieve stronger results by combining the P-Shot with shockwave therapy, testosterone optimization, or oral medications for erectile dysfunction treatment. These therapies help improve blood flow, smooth muscle tone, and erectile tissue function, complementing the regenerative benefits of platelet-rich plasma.

5. How many P-Shot treatments are needed?

Some men experience results after one session, while others may benefit from two or more treatments, spaced several months apart. Your provider will recommend a personalized treatment plan based on your medical history, response to the first injection, and aesthetic or functional goals.