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What Are the Worst Side Effects of Botox That You Should Be Aware of?

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Botox is one of the most common cosmetic procedures in the medical aesthetics market, and for good reason. Botox treatments are well-known and highly sought-after for their reliable safety profile, efficacy, and versatility—with over millions of satisfied patients yearly.

However, despite its longevity in the market and good safety record as one of the top nonsurgical cosmetic enhancements in the industry, Botox is not without potential risks and side effects.

As a patient, it’s normal to feel both curious and cautious about the side effects of Botox injections, especially the worst ones that can cause discomfort or harm to your well-being. The good news is that the worst facial Botox side effects are rare. Still, making a fully informed decision never hurts anyone.

Knowing the potential side effects of Botox on the face, from the common, temporary ones that typically resolve on their own, to those with more severe, adverse effects, is the best way to make a well-informed and educated decision as a consumer.

From Minor to Serious: Why Botox Side Effects Happen

Botox, or botulinum toxin type A, is a trusted and well-known brand of botulinum neurotoxin. It is clinically approved for aesthetic use by the Food and Drug Administration (FDA). Botox injections, when administered properly by a licensed provider, are generally viewed as safe and largely devoid of serious side effects and risks.

If this is the case, then you might be wondering when these side effects do happen. To get a better grasp of this, let’s first categorize these Botox-related side effects by severity, as knowing the difference between the two can help you be more well-informed and take more appropriate actions.

Minor Side Effects

These are well-localized, self-maintained, and reversible side effects that may appear posttreatment but typically disappear or resolve on their own after a few days.

Minor, temporary side effects of Botox include:

  • Swelling
  • Redness
  • Mild bruising
  • Localized pain (or pain as the needle punctures the skin)
  • Transient conditions (dry skin, minor headaches, temporary neck pain, and flu-like symptoms)

The causes for these benign, nonthreatening side effects are often needle-related and can happen due to tiny blood vessels breaking as the syringe penetrates your skin or because of your body’s natural response to being injected.

With these side effects, you usually have nothing to worry about, especially if you follow your provider’s aftercare instructions for optimal healing.

Rare But Serious Side Effects

Now, the more serious side effects of Botulinum toxin injections can be a cause for concern. But before diving into these, let’s understand why they happen in the first place.

Factors that increase potential risks and side effects include the following:

  • Accidental toxin spread: When Botox spreads beyond the intended injection site, which happens mostly as a result of incorrect placement or more severe needle trauma from mishandled Botulinum toxin injections
  • Fake Botox: When products from unverified sources or individuals who do not follow state requirements are injected into the body
  • Medical issues: Whether it’s muscle issues or allergic reactions to botulinum toxin, patients with existing health conditions are at higher risk of serious side effects

What Are the Worst Side Effects of Botox Injections?

Here are the more severe side effects of Botox to remember and watch out for as a patient. Keep in mind, however, that these are rare and wouldn’t usually happen when your Botox treatment is performed by an experienced master nurse injector like those at InjectCo.

You should seek medical help and contact a doctor or your healthcare provider immediately when you experience the following after your Botox injections:

1. Difficulty Swallowing or Breathing

Serious side effects like difficulty swallowing and/or breathing (shortness of breath), while very rare, can happen hours to weeks after a counterfeit or mishandled Botox treatment.

Difficulty swallowing (dysphagia) occurs when the botulinum toxin spreads from the injection site to unintended areas like your pharyngeal muscles, leading to weakness and trouble swallowing. You may also experience a similar complication and have trouble breathing (dyspnea) when the toxin weakens the muscles involved in breathing.

How to prevent: These side effects are uncommon, so they’re generally avoidable. Get Botox injections only from credible licensed providers, and steer clear of counterfeit products.

2. Vision Problems

When Botox near the eyes spreads beyond the intended muscle area or targeted injection site, problems like blurred vision, drooping eyelids, or double vision can occur.

Double vision, for instance, is an aftereffect that can happen months after Botox injections. This is usually a result of uneven muscle contractions around your eye, or your muscles relaxing beyond Botox’s intended effect posttreatment.

While these risks are on the more serious side, you still shouldn’t worry too much; they are typically mild and temporary and tend to resolve on their own, though it may take longer. To speed up the process and reverse the effects, your doctor may also offer special eyedrops.

How to prevent: Research the muscle-relaxing abilities of Botox for specific target areas, or consult with a qualified professional before your treatment to avoid unintended effects.

3. Severe Muscle Weakness

Muscle weakness occurs when Botulinum toxin spreads to unintended nearby muscles. It can also be caused by the Botox dosage affecting muscle control in a specific area.

While patients can expect temporary muscle weakness at the injection site after Botox, generalized muscle weakness, which has spread to surrounding areas, should be taken seriously. If symptoms worsen over time, contact a doctor immediately.

In rare cases, excessive, repeated, or prolonged Botox injections in the same area without rest or enough intervals in between can lead to weakened facial muscles over time. A more severe case would be muscle atrophy, or the wasting or thinning of muscles from lack of use.

How to prevent: Give your facial muscles enough time to rest and allow intervals (at least 3–4 months) between Botox injections.

4. Skin Infections

While rare, an infection may develop after Botox treatment if bacteria manage to enter the injection site. Infection from Botox may show through the following symptoms:

  • Increased pain and warmth in the injection area
  • Redness and tenderness that don’t go away
  • Pus (in the worst but very rare cases)

If this happens, contact your medical care provider right away. The good news is that, while infection is a serious side effect, it can be treated and resolved by taking prescription medicine like antibiotics promptly and properly.

How to prevent: Do your research thoroughly so you can safely avoid providers that perform unsafe practices, like not cleaning the injection site prior to pretreatment, or reusing old needles.

The Importance of Safe, FDA-Approved Botox

If there’s one thing the worst side effects of Botox all have in common, it’s that they are all rare and uncommon. This means that serious adverse effects are avoidable with expert care from master nurse injectors and physician assistants who only administer safe, FDA-approved Botox.

Takeaway

Receiving Botox injections from a qualified provider is a game-changer not only for your aesthetic goals but also for your overall health and well-being, which is why awareness of bad Botox side effects before you undergo treatment is key.

At InjectCo, our expert providers take these serious side effects into consideration in offering premium aesthetic services to our patients, ultimately tailoring treatment plans to your unique goals and needs.

Interested in learning more about Botox side effects? InjectCo’s master nurse injectors and physician assistants can help. Book a free consultation today, so you can minimize your worries and choose a safe and effective Botox treatment that works for you.

Frequently Asked Questions

What are the worst side effects of Botox injections?

The worst side effects of Botox include difficulty swallowing, breathing problems, vision problems, severe muscle weakness, and skin infections, though the good news is these are rare and not likely to happen with master nurse injectors who use authentic products.

Is Botox safe for the face?

Yes, Botox is safe for the face, backed by both FDA approval and patient testimonials. Botox Cosmetic is FDA-approved for cosmetic indications like wrinkle and facial line reduction.

Moreover, Botox can be safely used for therapeutic indications and medical conditions like chronic migraines, overactive bladder, and neck spasms or involuntary muscle activity, making it safe for body areas other than the face.

Is Botox 100% safe?

Realistically speaking, there isn’t a single cosmetic treatment that’s 100% safe since risks and side effects may occur, but Botox boasts a strong safety profile—with FDA approval and testimonials from satisfied patients to back it up.

At InjectCo, our master nurse injectors ensure that only FDA-approved, authentic Botox injections are administered at our premier clinic, ensuring patients’ safety at all times.

What are the long-term side effects of Botox?

The long-term side effects of Botox, particularly of prolonged, chronic Botox use in the same injection area without proper intervals, include muscle weakness and reduced toxin effectiveness.

Fortunately, this is avoidable when you give injected muscles enough time to return to normal activity, which is at least 3–4 months for Botox.

Written By:
Kiara DeWitt, BSN, RN, CPN, Advanced Clinical Nurse Injector


Kiara DeWitt, BSN, RN, CPN founded InjectCo in early 2021 while also heading up the neurosurgery + neurology unit at Cook Children’s Pediatric Hospital as lead clinical educator. After completing her Bachelor's degree at Texas Christian University, Kiara realized just how much the aesthetic medicine industry was missing, wishing it was more focused on ethical decision-making and building relationships. Kiara’s dream was to create an atmosphere for her patients where they feel loved, empowered, and comfortable. She believes in a “lead to serve” mentality, hoping to create a more personal connection with both her patients and team alike. Kiara curated a team of 13 professionals across eight clinics, six of which are in DFW, one in Houston, and one in Austin.
Kiara loves nothing more than creating a collaborating, educational approach with her team, and thrives on personal and professional growth opportunities. She hopes that her patients feel heard and encouraged at every InjectCo visit and that they are truly excited about their personalized and well-designed aesthetic treatment plan. This love for education and safety in the industry led her to later found Texas Academy of Medical Aesthetics, an accredited training program that specializes in a 100+ hour aesthetic injector internship where students are able to train and shadow at all eight of InjectCo’s clinics.


Kiara’s patients recognize her and the entire InjectCo team as highly skilled and extremely thorough clinicians. She hopes to continue being a knowledgeable and approachable resource for clinical injectors across the country who are hoping to grow and scale their aesthetic business.

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