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What Can Go Wrong with Dermal Fillers? Side Effects & Risks

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Dermal fillers are one of the most popular minimally invasive treatments globally, and it’s easy to see why. They add volume, soften wrinkles, and enhance features without the need for surgery. For many people, they’re a simple way to feel more confident and achieve a more youthful appearance.

But with all the benefits, you might still ask, “Are there any side effects associated with dermal fillers?”

The simple answer is yes. Just like any other cosmetic treatment, dermal filler procedures can come with a few side effects and rare risks.

But don’t let these side effects scare you. Most of the time, these are just minor issues, such as bruising or swelling, that typically fade after a few days. Many people never experience anything beyond mild reactions. Just make sure to maintain open communication with your aesthetic injector, so you know what to do in case you experience any issues.

If natural-looking results and safety matter to you, keep reading. We’ll break down what can go wrong and how you can respond, so you’ll feel prepared and informed as you consider or plan your next dermal filler treatment.

Common Side Effects of Facial Dermal Fillers

It’s normal to have some reactions after getting facial fillers. But while these effects are common, they still need attention.

In general, most aftercare tips are the same for everyone. However, it’s still best to consult your aesthetic injector before taking any action to ensure the advice is tailored to your specific treatment and skin needs.

To give you an idea of what these side effects are and what you can possibly do about them, here’s a quick breakdown.

1. Bruising

Bruising occurs when the needle punctures small blood vessels under the skin, resulting in a patch of discoloration. It often appears purple, blue, or yellow and typically occurs within a few hours of treatment.

What to Do

On the first day, use a cold compress for 10 to 15 minutes at a time, repeating every few hours. Skip alcohol, aspirin, and other blood thinners for a few days since they can make bruising worse and slow healing.

2. Swelling

Swelling is a natural response to both the filler and the injections. It can make the treated area look puffier than expected, especially on the lips or under the eyes. It typically peaks within 24 to 48 hours and then begins to decline.

What to Do

Apply a clean ice pack wrapped in a cloth to the area for short intervals. For the next day or two, sleep on your back with your head slightly elevated and avoid strenuous workouts to minimize blood flow to the face.

3. Redness and Tenderness

It’s common to see redness or feel warmth around the injection points. This phenomenon happens as the skin reacts to the tiny punctures and the filler adjusts in place. Tenderness may last anywhere from a few hours to a couple of days.

What to Do

Keep the area clean and avoid applying makeup until the redness has subsided to reduce the risk of irritation or infection. Do not touch or rub the area, as these actions can introduce bacteria or move the filler before it sets.

4. Pain or Sensitivity

Mild discomfort is normal, especially if several injections were done or if the lips were treated. You may experience tightness, throbbing, or a dull ache, but the discomfort should subside as the tissue heals.

What to Do

You can take acetaminophen (Tylenol) if needed. Avoid ibuprofen, aspirin, and blood-thinning medications, as they can worsen bruising. If the pain becomes stronger or spreads, contact your healthcare provider.

5. Lumps or Bumps

You might feel small, soft lumps under the skin after treatment. These complications can happen if the filler is placed close to the surface or spreads unevenly. Usually, they smooth out on their own as the filler settles.

What to Do

Do not massage the area unless your injector instructs you to. Doing it incorrectly can exacerbate the problem. If the bumps persist after a few weeks, your provider may suggest a quick fix, such as dissolving the filler with hyaluronidase.

6. Itching or Mild Rash

Some people notice mild itching or tiny red spots after treatment. This can be caused by the injections or by skincare products applied afterward. It’s usually harmless unless it worsens or spreads.

What to Do

Use a fragrance-free, gentle moisturizer to calm the skin. If you experience severe swelling, hives, or spreading redness, contact your healthcare provider immediately. These symptoms may indicate an allergic reaction that requires urgent medical attention.

7. Slight Asymmetry

Immediately after treatment, your face may appear uneven or slightly off. Such discomfort is often due to swelling, natural facial differences, or slight variations in the placement of the filler. It usually improves with time.

What to Do

Wait at least 2 weeks before judging the final result. Fillers need time to settle and even out. If asymmetry persists, your provider can make minor adjustments during a follow-up appointment.

Types of Dermal Fillers and Their Side Effects

You have several options when it comes to injectable fillers. Each type of filler is made with different ingredients and works best for specific areas of the face, so side effects can vary. While many reactions are common across wrinkle fillers, some side effects are more likely with a particular type.

Understanding the reactions associated with the type of filler you’re receiving enables you to prepare and ask the right questions prior to your appointment.

Hyaluronic Acid (HA) Fillers

Hyaluronic acid fillers are among the most widely used. They contain a substance your body naturally produces to keep skin hydrated and firm. Many people choose HA fillers because the results look smooth and natural, and they can be safely dissolved if needed.

Potential Side Effects of HA Fillers

  • Swelling that lasts a few days
  • Temporary bumps or uneven texture
  • A blue tint under the skin (Tyndall effect) if injected too close to the surface
  • Rare allergic reactions
  • Migration (if not placed properly)

Calcium Hydroxylapatite (CaHA) Fillers

Calcium hydroxylapatite is a mineral-like substance found in bones. It has a thicker texture than HA, making it ideal for deeper facial wrinkles and restoring volume. People often choose CaHA because it lasts longer and encourages collagen production over time.

Possible Side Effects of CaHA Fillers

  • Firmness or stiffness in the treated area
  • Swelling that lasts longer than HA fillers
  • Possible nodules under the skin
  • Cannot be dissolved with an enzyme like HA fillers

Poly-L-lactic Acid (PLLA) Fillers

Poly-L-lactic acid is a synthetic material that helps your skin produce collagen. Unlike most fillers, PLLA doesn’t give instant results. Changes develop slowly over several months, which makes it a good choice for restoring volume with subtle, long-lasting results.

Possible Side Effects of PLLA Fillers

  • Delayed lumps under the skin
  • Redness or inflammation weeks after treatment
  • Longer recovery time because results are gradual
  • Requires multiple sessions

Polymethylmethacrylate (PMMA) Fillers

PMMA fillers contain tiny, smooth beads that remain under the skin to provide long-term support. They are often used to treat deep wrinkles, acne scars, and structural improvements. People choose PMMA for its semi-permanent results, especially if they want a gradual change over time.

Possible Side Effects of PMMA Fillers

  • Higher risk of nodules if injected incorrectly
  • Permanent results that cannot be reversed
  • Possible granulomas (inflammatory reactions)
  • More likely to cause complications if too much is injected

What Increases the Risk of Side Effects After a Dermal Filler Procedure?

Although there’s a slight chance of experiencing dermal filler long-term side effects, it’s still important to take precautions before and after treatment. Your risk depends on several factors, including the injector’s experience, the type of filler used, your health, and how well you follow aftercare instructions.

Unqualified or Inexperienced Injectors

When someone without proper training or experience performs injections, the likelihood of complications increases. Poor technique can lead to problems such as filler being placed too close to the surface, injected into a blood vessel, or placed in the wrong layer of the skin.

Using Unregulated or Counterfeit Products

Trying to save money with off-brand or black-market injectable fillers is risky. These products often skip safety testing and may contain harmful or unknown substances.

Preexisting Health Conditions

Certain health issues, such as autoimmune disorders, bleeding problems, or skin infections, can increase the risk of complications. The body may react differently, which could lead to increased inflammation or slower healing. Always provide your provider with your complete medical history so they can confirm that fillers are safe for you or suggest an alternative option.

Poor Aftercare or Ignoring Instructions

What you do after your treatment is just as important as the filler injection itself. Not following aftercare directions can lead to irritation, swelling, or infection. To support proper healing and maintain the best results, follow your injector’s guidelines closely.

Choose a Dermal Filler Clinic That Puts Your Safety First

The best way to lower your risk of serious dermal filler side effects is to choose a clinic that prioritizes your safety above anything else. This means working with a licensed injector or aesthetic nurse who is knowledgeable about facial anatomy and uses FDA-approved products.

Seek providers who offer detailed consultations, show real before-and-after photos, and explain risks and aftercare clearly. This approach enhances your confidence in the process and guarantees that no questions remain unanswered.

Our team of master nurse-injectors and physician assistants at InjectCo fits this standard. We rely on experienced, licensed professionals. We use FDA‑approved fillers and provide transparent pricing and real results. We talk you through risks and follow up until you feel comfortable.

Book a free virtual consultation at InjectCo today. Let us help you achieve the look you desire with care you can trust.

Frequently Asked Questions

What are the negative effects of fillers?

Dermal filler treatments can cause temporary adverse effects like swelling, bruising, redness, pain, or itching near the injection site. In rare cases, more serious complications can occur, such as infections, allergic reactions, or uneven results that may need immediate medical attention. Choosing an experienced and qualified injector significantly reduces these risks.

Who should avoid facial fillers?

Fillers aren’t recommended for people who are pregnant, breastfeeding, or allergic to any of the ingredients used. They’re also not ideal for those with active skin infections, autoimmune conditions, bleeding disorders, or a history of keloid scarring. Always consult a qualified professional to review your medical history and decide if fillers are the right option for you.

Are fillers safe for the face?

Yes, facial fillers are generally safe when administered by a board-certified dermatologist, plastic surgeon, or master nurse-injector who has received proper training in facial injections. Complications such as infection, lumps, or tissue damage can occur if the filler is injected incorrectly or used in the wrong area. To stay safe, make sure your injector uses FDA-approved products and has a thorough understanding of facial anatomy.

Do dermal fillers have side effects?

Yes, dermal fillers can cause side effects, the most common of which are bruising, swelling, tenderness, or redness around the injection site. To lower your risk, always work with a licensed injector who understands facial anatomy and uses approved products. It also helps to review dermal filler side effects before-and-after photos during your consultation so you know what to expect.

Written By:
Dr. Adrian Cole, MD


Dr. Adrian Cole, MD, is a Medical Advisor with over a decade of experience in medical aesthetics and wellness. He provides clinical guidance on patient safety, treatment planning, and evidence-based protocols across a broad range of services, including injectables, skin health, and medical weight management. With extensive experience training healthcare providers, Dr. Cole plays a key role in shaping best practices and supporting safe, results-driven care within modern aesthetic and wellness clinics.

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