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What Is The Difference Between Botox And Xeomin?

Table Of Contents

Botox was the first Botulinum toxin A product to gain FDA approval for cosmetic usage in the United States. It remained the only such product for nearly two decades. However, now multiple alternatives exist: DysportXeomin, and Jeuveau are the ones most commonly used. Xeomin is one of the more interesting options because it is the biggest variation of the original Botox formula.

At Injectco, our clinical injectors are familiar with and use both products. Patients may find they prefer the results of one over the other, but both can help treat and prevent wrinkle formation.

Botox vs. Xeomin

Botox and Xeomin both have FDA approvals for cosmetic uses. Unlike Botox, Xeomin received its first FDA approval for cosmetic purposes in 2011. This is roughly twenty years after Botox Cosmetic first gained approval.

What They Treat

Botox and Xeomin are used on-label and off-label for the same procedures. The two products have the following FDA approval history for cosmetic uses:

  • Botox: glabellar lines, crow’s feet
  • Xeomin: glabellar lines

Both products have several medical approvals as well including for cervical dystonia and blepharospasm. However, providers can safely use the products off-label to treat forehead lines, excessive sweating, migraines, and fine lines and wrinkles around the face.

How They Work

Botox is made from Botulinum toxin type A which is produced by the same bacteria that causes botulism. Botulism causes muscle relaxation to an extreme. However, when Botulinum toxin A is isolated, purified, and mixed with other ingredients, it can cause localized freezing of muscles safely. There is almost no risk of developing botulism with the normal dosages administered.

Xeomin is derived from the same toxin. However, it does not contain any preservative proteins like Botox and Dysport. This means that you cannot develop antibodies to Xeomin like you can with Botox or other neurotoxin products. Therefore, Xeomin is an amazing product for people who have developed immunity to traditional Botox.

Limiting muscle contractions that cause wrinkles can also help prevent the formation of permanent wrinkles in the future. Xeomin and Botox both provide great results and work in nearly identical ways.

Common Side Effects:

Botox and Xeomin carry few side effects. A few possible side effects include:

  • Headache
  • Pain, swelling, or redness at the injection site
  • Flu-like symptoms

 Anecdotal evidence from providers and patients may suggest that Xeomin causes fewer or less severe side effects, particularly headaches. If you find that you often experience side effects after Botox injections, you may consider trying Xeomin next time to see if you see an improvement in side effects following neurotoxin injections.

Conclusion

Botox and Xeomin carry few side effects. A few possible side effects include:

  • Headache
  • Pain, swelling, or redness at the injection site
  • Flu-like symptoms

 Anecdotal evidence from providers and patients may suggest that Xeomin causes fewer or less severe side effects, particularly headaches. If you find that you often experience side effects after Botox injections, you may consider trying Xeomin next time to see if you see an improvement in side effects following neurotoxin injections.

Whether you choose Botox or Xeomin, Injectco can help you achieve all of your aesthetic goals. Along with neuromodulator injections, Injectco provides top-of-the-line dermal fillers and Wegovy weight loss injections. With three locations in the Dallas-Fort Worth area, you can likely find one near you.To learn more and schedule an appointment, use our online scheduling tool or call us at 817-214-2312.

Written By:
Dr. Adrian Cole, MD


Dr. Adrian Cole, MD, is a Medical Advisor with over a decade of experience in medical aesthetics and wellness. He provides clinical guidance on patient safety, treatment planning, and evidence-based protocols across a broad range of services, including injectables, skin health, and medical weight management. With extensive experience training healthcare providers, Dr. Cole plays a key role in shaping best practices and supporting safe, results-driven care within modern aesthetic and wellness clinics.

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